Posts Tagged ‘calcium ascorbate’

Stroke Morbidity Tripled for Anemic Patients

Wednesday, June 20th, 2012

Iron is necessary for oxygen to be transported in the blood. Iron binds to oxygen in the bloodstream and carries it to all of the cells in the body that need the oxygen molecules to perform. Without iron, oxygen cannot be delivered to cells and the cells die.

Iron is also needed to diffuse oxygen through muscle cells, providing us with energy when we need it. Iron is used in DNA synthesis and cell division; helping your body to age more slowly and renew itself when necessary. Iron is also necessary for producing connective tissues, neurotransmitters, and maintaining the immune system.

Iron deficiency can cause anemia, the condition of having a low red blood cell count or low quantity of hemoglobin. Symptoms include fatigue, paleness, fast or irregular heartbeat, shortness of breath, cognitive or learning problems, cold hands and feet, and headaches.

Studies on anemia have shown that people who have a heart attack, heart failure, or kidney disease are more likely to die within a year if they are anemic. Stroke patients are now being added to that list and anemia is considered a “potent predictor of dying throughout the first year after a stroke” according to Jason Sico, M.D., lead researcher and assistant professor of neurology at Yale University School of Medicine in New Haven, Connecticut.

The study was conducted on 3,750 men treated for their first ischemic stroke, the most common type of stroke. The study reported the following:

1) Patients with severe anemia were 3.5 times more likely to die while still in the hospital and 2.5 times more likely to die within a year.

2) Stroke survivors with moderate anemia were twice as likely to die within six to 12 months after a stroke.

3) People with mild anemia were about 1.5 times more likely to die within six to 12 months after a stroke.

An important thing to remember when trying to keep up your iron levels is that lots of minerals compete for iron uptake in the digestive tract. Many people believe they are taking enough iron, but then their other supplements are preventing the iron from being absorbed. Calcium is the main culprit in iron not being properly absorbed.

On the other hand, there are vitamins that can help iron to be absorbed. Ascorbic acid, or vitamin C, is a potent enhancer of iron absorption. Studies have shown that vitamin C added to a meal can increase iron absorption by up to five times.

To avoid the interaction between calcium and iron, the National Institutes of Health recommends taking calcium supplements at bedtime. This brings to question the best vitamin C supplements to take with your meals for maximum iron absorption.

Most vitamin C supplements on the market are calcium ascorbate, which gives you a healthy dose of calcium with your vitamin C. There are buffered vitamin C products that are much easier on the stomach and more beneficial to take with meals, two of which are sodium ascorbate and C-Salts. Or, if you can tolerate the acidity of vitamin C without a buffering agent then pure vitamin C powder may the best vitamin C supplement option for you.

About the Author: Stacy A. Pessoney is Wholesale Nutrition’s Chief Editor and Communications Research Director. She has a strong interest in helping people achieve greater brain and body health with the help of vitamins and supplements, focusing on sodium ascorbate in the form of vitamin C powder. Wholesale Nutrition has provided the world with the best vitamin C and wholesale vitamins since 1970. Visit to buy high-quality discount vitamins today!



This entire article may be reprinted free of charge provided that the “About the Author” section of the article, sources, and all links in the article are included. For shorter quotations, a clear link to the blog post or Wholesale Nutrition is sufficient.

Reversing Degenerative Disc Disease

Monday, April 30th, 2012

If you’ve been diagnosed with degenerative disc disease, don’t make the mistake of thinking that you just have to accept the fact that you will always have a bad back or neck and that there is nothing you can do about it without surgery. Most people automatically lose faith in healing the discs in their spine when they hear the word “degenerative” and assume that this means “it’s all downhill from here”. It’s just simply not true.

Most doctors will briefly explain that degenerative disc disease is basically due to aging. As we age, our spines break down, discs lose cushioning, and eventually surgery is needed. Even then, there is a chance that the surgery will not help, decrease mobility, or even increase the pain. While surgery is necessary for many people, it doesn’t change the fact that you can fight degenerative disc disease and in some cases, completely reverse the damage.

Think of the discs in your back as jelly-filled donuts. They’re like a cushion, almost liquid in the center, with a more firm layer that is still flexible on the outside. These discs are shock absorbers for the spine. Every time we twist, sit, lift, walk, lie down, or do pretty much anything, these discs are put to work. Disc degeneration is most often seen in the neck or lumbar spine, or lower back, because these areas take on the most stress for most common movements.

Our spinal discs are composed of connective tissues, just like our organs, skin, and bones. These tissues are constantly breaking down, experiencing normal cell death, stress and injury. If your discs are breaking down faster than your body can regenerate healthy cells, then the outer layer of the disc begins to thin out. This is when the gooey center of the disc can experience too much pressure and start to balloon out further than normal. This is what causes bulging discs, herniated discs, and pinched nerves.

When we experience a break down in our discs, our bodies react with inflammation to direct collagen and elastin to the correct areas for repair. Collagen and elastin create new, soft, flexible, strong tissues that give damaged discs a new lease on life. If collagen and elastin are not available, then hard, weak, brittle patches are formed from cholesterol to correct damage. This is also the process that contributes to hardened arteries.

To produce collagen and elastin, our bodies need a sufficient amount of vitamin C. We stress “sufficient” because what is generally accepted as a recommended daily allowance is actually only the amount needed for a healthy person to avoid becoming deficient. Since vitamin C, or ascorbic acid, must be consumed through diet or vitamins and supplements, it is easy to become deficient. The more stress, inflammation, chemicals, infections, diseases, or allergens we’re exposed to, the more vitamin C we need.

Vitamin C deficiency is recognized by many doctors and researchers as the underlying cause of a majority of degenerative, infectious, and inflammatory diseases. Ask your doctor about supplementing with the best vitamin C, like sodium ascorbate vitamin C powder or calcium ascorbate. Higher dosages than you think may be needed to correct your degenerative disc problem, so work with your doctor on monitoring your health and progress.


This entire article may be reprinted free of charge provided that the “About the Author” section of the article, sources, and all links in the article are included. For shorter quotations, a clear link to the blog post or Wholesale Nutrition is sufficient.

About the Author: Phil Le Breton is owner at Wholesale Nutrition. He has a strong interest in helping people achieve greater brain and body health with vitamins and supplements, with an emphasis on vitamin C powder. Wholesale Nutrition has provided the world with the best vitamin C and wholesale vitamins since 1970. Visit to buy high-quality discount vitamins today!


Tuesday, April 3rd, 2012

Here at Wholesale Nutrition, we highly value valid research related to vitamins and supplements. We are continually impressed with the reports from Orthomolecular Medicine News Service and would like to share some of their content with you from time to time. We hope you find it as fascinating as we do!

What Form is Best?

(OMNS, December 8, 2009) Vitamin C is commonly taken in large quantities to improve health and prevent asthma, allergies, viral infection, and heart disease [1,2]. It is non-toxic and non-immunogenic, and does not irritate the stomach as drugs like aspirin can. Yet vitamin C (L-ascorbic acid) is acidic. So, a common question is, what are the effects from taking large quantities?

Ascorbic acid is a weak acid (pKa= 4.2) [3], only slightly stronger than vinegar. When dissolved in water, vitamin C is sour but less so than citric acid found in lemons and limes. Can large quantities of a weak acid such as ascorbate cause problems in the body? The answer is, sometimes, in some situations. However, with some simple precautions they can be avoided.

Acid in the Mouth
First of all, any acid can etch the surfaces of your teeth. This is the reason the dentist cleans your teeth and warns about plaque, for acid generated by bacteria in the mouth can etch your teeth to cause cavities. Cola soft drinks contain phosphoric acid, actually used by dentists to etch teeth before tooth sealants are applied. Like soft drinks, ascorbic acid will not cause etching of teeth if only briefly present. Often, vitamin C tablets are coated with a tableting ingredient such as magnesium stearate which prevents the ascorbate from dissolving immediately. Swallowing a vitamin C tablet without chewing it prevents its acid from harming tooth enamel.

Chewable Vitamin C Tablets
Chewables are popular because they taste sweet and so are good for encouraging children to take their vitamin C [4]. However, some chewable vitamin C tablets can contain sugar and ascorbic acid which, when chewed, is likely to stick in the crevices of your teeth. So, after chewing a vitamin C tablet, a good bit of advice is to rinse with water or brush your teeth. But the best way is to specifically select non-acidic vitamin C chewables, readily available in stores. Read the label to verify that the chewable is made entirely with non-acidic vitamin C.

Stomach Acidity
People with sensitive stomachs may report discomfort when large doses of vitamin C are taken at levels to prevent an acute viral infection (1,000-3,000 milligrams or more every 20 minutes) [1, 5]. In this case the ascorbic acid in the stomach can build up enough acidity to cause heartburn or a similar reaction. On the other hand, many people report no problems with acidity even when taking 20,000 mg in an hour. The acid normally present in the stomach, hydrochloric acid (HCl), is very strong: dozens of times more acidic than vitamin C. When one has swallowed a huge amount of ascorbate, the digestive tract is sucking it up into the bloodstream as fast as it can, but it may still take a while to do so. Some people report that they seem to sense ascorbic acid tablets “sitting” at the bottom of the stomach as they take time to dissolve. It is fairly easy to fix the problem by using buffered ascorbate, or taking ascorbic acid with food or liquids in a meal or snack. When the amount of vitamin C ingested is more than the gut can absorb, the ascorbate attracts water into the intestines creating a laxative effect. This saturation intake is called bowel tolerance. One should reduce the amount (by 20-50%) when this occurs [1].

Acid Balance in the Body
Does taking large quantities of an acid, even a weak acid like ascorbate, tip the body’s acid balance (pH) causing health problems? No, because the body actively and constantly controls the pH of the bloodstream. The kidneys regulate the acid in the body over a long time period, hours to days, by selectively excreting either acid or basic components in urine. Over a shorter time period, minutes to hours, if the blood is too acid, the autonomic nervous system increases the rate of breathing, thereby removing more carbon dioxide from the blood, reducing its acidity. Some foods can indirectly cause acidity. For example, when more protein is eaten than necessary for maintenance and growth, it is metabolized into acid, which must be removed by the kidneys, generally as uric acid. In this case, calcium and/or magnesium are excreted along with the acid in the urine which can deplete our supplies of calcium and magnesium [6]. However, because ascorbic acid is a weak acid, we can tolerate a lot before it will much affect the body’s acidity. Although there have been allegations about vitamin C supposedly causing kidney stones, there is no evidence for this, and its acidity and diuretic tendency actually tends to reduce kidney stones in most people who are prone to them [1,7]. Ascorbic acid dissolves calcium phosphate stones and dissolves struvite stones. Additionally, while vitamin C does increase oxalate excretion, vitamin C simultaneously inhibits the union of calcium and oxalate. [1,2].

Forms of Vitamin C
Ascorbate comes in many forms, each with a particular advantage. Ascorbic acid is the least expensive and can be purchased as tablets, timed release tablets, or powder. The larger tablets (1000-1500 mg) are convenient and relatively inexpensive. Timed-release tablets contain a long-chain carbohydrate which delays the stomach in dissolving the ascorbate, which is then released over a period of hours. This may have an advantage for maintaining a high level in the bloodstream. Ascorbic acid powder or crystals can be purchased in bulk relatively inexpensively. Pure powder is more quickly dissolved than tablets and therefore can be absorbed somewhat faster by the body. Linus Pauling favored taking pure ascorbic acid, as it is entirely free of tableting excipients.

Buffered Ascorbate
A fraction of a teaspoon of sodium bicarbonate (baking soda) has long been used as a safe and effective antacid which immediately lowers stomach acidity. When sodium bicarbonate is added to ascorbic acid, the bicarbonate fizzes (emitting carbon dioxide) which then releases the sodium to neutralize the acidity of the ascorbate.

Calcium ascorbate can be purchased as a powder and readily dissolves in water or juice. In this buffered form ascorbate is completely safe for the mouth and sensitive stomach and can be applied directly to the gums to help heal infections [8]. It is a little more expensive than the equivalent ascorbic acid and bicarbonate but more convenient. Calcium ascorbate has the advantage of being non-acidic. It has a slightly metallic taste and is astringent but not sour like ascorbic acid. 1000 mg of calcium ascorbate contains about 110 mg of calcium.

Other forms of buffered ascorbate include sodium ascorbate and magnesium ascorbate [9]. Most adults need 800 – 1200 mg of calcium and 400-600 mg of magnesium daily [6]. The label on the bottle of all these buffered ascorbates details how much “elemental” mineral is contained in a teaspoonful. They cost a little more than ascorbic acid.

Buffered forms of ascorbate are often better tolerated at higher doses than ascorbic acid, but they appear not to be as effective for preventing the acute symptoms of a cold. This may be because after they are absorbed they require absorbing an electron from the body to become effective as native ascorbate [1]. Some of types of vitamin C are proprietary formulas that claim benefits over standard vitamin C [9].

Liposomal Vitamin C
Recently a revolutionary form of ascorbate has become available. This form of vitamin C is packaged inside nano-scale phospholipid spheres (“liposomes”), much like a cell membrane protects its contents. The lipid spheres protect the vitamin C from degradation by the environment and are absorbed more quickly into the bloodstream. Liposomes are also known to facilitate intracellular uptake of their contents, which can cause an added clinical impact when delivering something such as vitamin C. This form is supposed to be 5-10 fold more absorbable than straight ascorbic acid. It is more expensive than ascorbic acid tablets or powder.

Ascorbyl Palmitate
Ascorbyl palmitate is composed of an ascorbate molecule bound to a palmitic acid molecule. It is amphipathic, meaning that it can dissolve in either water or fat, like the fatty acids in cell membranes. It is widely used as an antioxidant in processed foods, and used in topical creams where it is thought to be more stable than vitamin C. However, when ingested, the ascorbate component of ascorbyl palmitate is thought to be decomposed into the ascorbate and palmitic acid molecules so its special amphipathic quality is lost. It is also more expensive than ascorbic acid.

Natural Ascorbate
Natural forms of ascorbate derived from plants are available. Acerola, the “Barbados cherry,” contains a large amount of vitamin C, depending on its ripeness, and was traditionally used to fight off colds. Tablets of vitamin C purified from acerola or rose hips are available but are generally low-dose and considerably more expensive than ascorbic acid. Although some people strongly advocate this type, Pauling and many others have stated that such naturally-derived vitamin C is no better than pure commercial ascorbate [2,9]. Bioflavonoids are antioxidants found in citrus fruits or rose hips and are thought to improve uptake and utilization of vitamin C. Generally, supplement tablets that contain bioflavonoids do not have enough to make much difference. For consumers on a budget, the best policy may be to buy vitamin C inexpensively whether or not it also contains bioflavonoids. Citrus fruits, peppers, and a number of other fruits and vegetables contain large quantities of bioflavinoids. This is one more reason to eat right as well as supplement.


[1] Hickey S, Saul AW (2008) Vitamin C: The Real Story, the Remarkable and Controversial Healing Factor. ISBN-13: 9781591202233

[2] Pauling L (1986) How to Live Longer and Feel Better, by Linus Pauling (Revised version, 2006) ISBN-13: 9780870710964

[3] Handbook of Chemistry and Physics (2004), CRC Press, ISBN-13: 978-0849304859

[4] (Ideas on how to get children to take vitamin C.)

[5] Cathcart RF (1981) Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy. Med Hypotheses. 7:1359-1376.

[6] Dean C (2006) The Magnesium Miracle. (2006) ISBN-13: 9780345494580


[8] (Healing gums with buffered ascorbate.)
See also: Riordan HD, Jackson, JA (1991) Topical ascorbate stops prolonged bleeding from tooth extraction. J Orthomolecular Med, 6:3-4, p 202. or

[9] (Information about different forms of vitamin C)


Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information:

The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

Editorial Review Board:

Carolyn Dean, M.D., N.D.
Damien Downing, M.D.
Michael Gonzalez, D.Sc., Ph.D.
Steve Hickey, Ph.D.
James A. Jackson, PhD
Bo H. Jonsson, MD, Ph.D
Thomas Levy, M.D., J.D.
Jorge R. Miranda-Massari, Pharm.D.
Erik Paterson, M.D.
Gert E. Shuitemaker, Ph.D.

Andrew W. Saul, Ph.D., Editor and contact person. Email: [email protected]

Original post at

Vitamin C Vital to Dental Health

Thursday, February 23rd, 2012

Bleeding gums are not only a sign of poor dental health, but also a sign of low vitamin C levels. Scurvy, or vitamin C deficiency, is characterized by hair and tooth loss, joint pain and swelling, bleeding, bruising easily, and fatigue. This is because vitamin C is needed to create collagen, the connective tissue that binds together everything in our bodies. Without it, you literally begin to fall apart.

Our bodies are constantly breaking down old tissues and rebuilding new ones with collagen. Even our bones go through this process. Because the gums use so much collagen, you will quickly notice if they’re not getting enough. It has been established that our gums turn over about 20% of their collagen every day.

Collagen builds up the gums, giving them the strength and health that they need to support circulation and tooth adherence. Receding gums also contribute to a receding gum line and tooth sensitivity that can be quickly overcome or vastly improved by consuming adequate amounts of vitamin C. Every time our teeth touch each other they use a little vitamin C. This is why you will notice that the teeth that touch first when you gently close your jaw will have the most gum recession, decay, and plaque. People that grind or clench their teeth will especially notice extra sensitivity and gum problems because of their increased need for vitamin C every day.

Inadequate vitamin C can lead to periodontal disease by opening up the tooth “pockets”. This can cause the gums to bleed and the teeth to fall out, but still at a slower rate than vitamin C deficiency does. Vitamin C keeps the bone around the root of the tooth from shrinking and causing the tooth to loosen by allowing the absorption of calcium into the bone and keeping the bone and tooth matrix strong.

Vitamin C also inhibits the formation of plaque and tartar. In the same manor that vitamin C removes plaque from artery walls and prevents new plaque from forming, it prevents and removes plaque from teeth. In fact, it has been referred to as the “invisible toothbrush” because in studies, people that only brushed their teeth once per day and consumed higher amounts of vitamin C had less plaque and bacteria on their teeth than the other participants that brushed their teeth two or more times per day. Pay attention to your gums if you start supplementing. You could notice your gums tightening as early as the first day.

The “Recommended Daily Allowance” of vitamins is based on the prevention of deficiency and scurvy in a perfectly healthy person, not the individual needs of someone specific. According to the Linus Pauling Institute, an average amount needed per day to prevent heart disease, periodontal disease and cancer is around 10,000 mg per day. That’s the equivalent of about 100 large oranges per day or 72 cups of orange juice per day. It’s no wonder that over 95% of Americans have tooth decay, periodontal disease or gingivitis.

The best vitamin C for dental health is sodium ascorbate. Mineral ascorbates, or mineral salts of sodium ascorbate, lack the acidity of other forms of vitamin C, therefore causing less tooth erosion and stomach discomfort in higher doses. If you take vitamin C in the form of calcium ascorbate, make sure that you do not exceed 2500 mg of calcium in a 24 hour period. Because of the dangers of overdosing on calcium, sodium ascorbate, like the vitamin c found in our vitamin C powder, is recommended for higher vitamin C intakes.

About the Author: Phil Le Breton is owner at Wholesale Nutrition. He has a strong interest in helping people achieve greater brain and body health with vitamins and supplements, with an emphasis on vitamin C powder. Wholesale Nutrition has provided the world with the best vitamin C and wholesale vitamins since 1970. Visit to buy high-quality discount vitamins today!



This entire article may be reprinted free of charge provided that the “About the Author” section of the article, sources, and all links in the article are included. For shorter quotations, a clear link to the blog post or Wholesale Nutrition is sufficient.